Self-antigen recognition by follicular lymphoma B-cell receptors.

Article Title: Self-antigen recognition by follicular lymphoma B cell receptors Running Title: A subset of lymphomas possess self-reactive BCRs

Spontaneous Follicular Exclusion of SHP1-deficient B Cells Is Conditional on the Presence of Competitor Wild-type B Cells

Engagement of antigen receptors on mature B lymphocytes is known to block cell entry into lymphoid follicles and promote accumulation in T cell zones, yet the molecular basis for this change in cell distribution is not understood. Previous studies have shown that follicular exclusion requires a threshold level of antigen receptor engagement combined with occupancy of follicles by B cells withou...

From the Regulation of B Cell Survival to Potential Novel Approaches for Lymphoma Therapy

Apoptosis or programmed cell death plays an important role in the regulation of B cell survival. Failures in the apoptotic signaling can lead to autoimmune diseases or cancer. Moreover, apoptosis is a major mode of cell death in cancer therapy, and resistance to therapy is often associated with disturbances in the apoptotic signaling. The detailed knowledge of the apoptotic signaling pathways c...

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.

Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylation sequons, NX(S/T). These potential glycosylation sites are introduced by somatic mutation and are lymphoma-specific, pointing to their invol...

Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1.

Follicular lymphomas recapitulate the architecture of germinal centers (GCs) of normal secondary lymphoid follicles. Using an in vitro binding assay, it has recently been demonstrated that the normal B lymphocytes bind to GCs. This interaction is mediated by a receptor-ligand pair consisting of the beta 1 integrin very late antigen 4 (VLA-4) on the B cell, and the vascular cell adhesion molecul...